VDR is a gene that encodes a protein that acts as a receptor for vitamin D, which regulates bone development and calcium absorption. A variant of the gene (rs2228570, FokI polymorphism) is associated with a lower bone mineral density in prepubescent girls of white background.
The hnRNP C1/C2 component of the nuclear vitamin D receptor complex interacts with promoter regions of genes that are responsive to 1,25-dihydroxyvitamin D3 and can induce their transcription. The interaction is regulated through the reciprocal pattern and the temporal occupancy of the VDRE between the two components. It is also affected by chromosomal location and binding preferences for specific hormones. Microarray studies of human cells indicate that over 100 genes have a distinct VDRE located in their promoters. The VDRE is occupied by transcription repressors in the absence of 1,25-dihydroxyvitamin D3. The 1,25-dihydroxyvitamin D3-VDR complex binds to these genes, resulting in the recruitment of hnRNP C1/C2 and other proteins that can compete with the repressors and initiate transcription.
A virtual data room (VDR) is an online repository for information and documents relevant to legal, business, or proceedings that are restricted in viewing printing, downloading, or viewing. It utilizes a central server as well as an extranet connection that is an Internet connection that has restricted access to allow controlled log-on for set times at which users can browse the documents and data.
VDRs are primarily used by investment banks and companies involved in mergers and acquisitions. They need an encrypted platform to share information with investors or potential buyers in a transparent way, and due diligence can require huge amounts of data. Life science firms also use VDRs for everything from clinical trials results to HIPAA compliance documents.